The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers

Reduced-intensity conditioning (RIC) regimens are increasingly used in allogeneic stem-cell transplantation (SCT). This study published in Leukemia reveals the marked differences in outcome between RIC regimens. The FM regimen is more myelosuppressive and toxic but controls disease better. FB was associated with improved survival in patients transplanted in remission.

Comparison between two fludarabine-based reduced-intensity conditioning regimens before allogeneic hematopoietic stem-cell transplantation: fludarabine/melphalan is associated with higher incidence of acute graft-versus-host disease and non-relapse mortality and lower incidence of relapse than fludarabine/busulfan

Reduced-intensity conditioning (RIC) regimens are increasingly used in allogeneic stem-cell transplantation (SCT). This study published in Leukemia reveals the marked differences in outcome between RIC regimens. The FM regimen is more myelosuppressive and toxic but controls disease better. FB was associated with improved survival in patients transplanted in remission.

Treatment for anemia with erythropoietic agents in patients with non-myeloid hematological malignancies: a clinical practice guideline

Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia