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Tuesday, 13 May, 2008


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Lung Cancer
Glypican-3 Gene Function In Regulating Body Size Helps Inform Novel Cancer Treatments
GSL Receives Authorisation In Europe For Oral Hycamtin(R) (topotecan Hard Capsules) For The Treatment Of Relapsed Small Cell Lung Cancer
Astrazeneca Files Marketing Application In Europe For EGFR Inhibitor Gefitinib In Locally Advanced Pre-Treated Non-Small Cell Lung Cancer (NSCLC)
Synergistic Growth Inhibitory Effect Of Herbal Extracts Against HCC And Lung Cancer Cells

Hot Topic
NEW LUNG CANCER GUIDELINES OPPOSE GENERAL CT SCREENING
Sept 10 2007
New evidenced-based guidelines from the ACCP recommend against the use of LDCT for the general screening of lung cancer. Published as a supplement to the September issue of CHEST the guidelines cite there is little evidence to show lung cancer screening impacts mortality in patients, including those who are considered at high risk for the disease.


Keeping you up to date with the latest clinical trial information

X-ray of lungs

Current Strategies in the Treatment of Advanced Non-small Cell Lung Cancer


The field of lung cancer therapy remains dynamic. In the last several years, erlotinib and pemetrexed have gained approval for the treatment of lung cancer, and drugs such as bevacizumab have demonstrated success in combination with chemotherapy as first-line therapy against NSCLC.

Stethascope

The Need for an Individual Approach to Lung Cancer Treatment


Heidi Greulich and colleagues [1] have demonstrated the significance of insertion mutations in the epidermal growth factor receptor (EGFR) (exon 20) for tumorigenesis and responsiveness to tyrosine kinase inhibitors (TKIs) in lung cancers.

Lungs

Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
Tyrosine kinases (TKs) are found only in metazoans, where they regulate multiple critical multicellular functions, including growth, differentiation, apoptosis, adhesion, and mobility.

Biomarkers in Screening Participants For Lung Cancer
OBJECTIVES:

Identify and validate biomarkers for the early detection of lung cancer in individuals at low- or high-risk for smoking-related cancers. Identify preneoplastic cellular changes and lesions in these patients.

OUTLINE: This is a multicenter study. Participants are stratified according to lung cancer status (diagnosed or nondiagnosed lung cancer vs with or without increased risk vs diagnosed nonmalignant nodules) and participating site.

Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary function testing, multidetector chest CT scan, sputum induction, and phlebotomy.

Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the same tests and scans as in group 1. Some participants may undergo fluorescence or ultrathin bronchoscopy based upon CT scan results with transbronchial or endobronchial biopsies. Some participants may undergo lung resection. Tissue samples are collected from surgery or biopsy.

PROJECTED ACCRUAL: A total of 1,450 participants will be accrued for this study.
Newly FDA-approved drugs

Tarceva (erlotinib) Tablets
Company: OSI/Genentech
Approved: November 18, 2004
Approvals process Treatment for: Non-Small Cell Lung Cancer (NSCLC)
Tarceva is a Human Epidermal Growth Factor Receptor Type 1/Epidermal Growth Factor Receptor (HER1/EGFR) tyrosine kinase inhibitor indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen.
Guidelines Watch
A round up of the latest Clinical Guidelines from the National Guideline Clearinghouse (NGC)

ACCP Issues New Lung Cancer Guidelines - September 2007
New guidelines from the American College of Chest Physicians recommend against low-dose helical CT, serial chest radiographs, or sputum cytologic evaluation to screen for lung cancer.

Guidelines for preventing health-care--associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee
Centers for Disease Control and Prevention - Federal Government Agency [U.S.]. 2004 Mar 26. 36 pages. NGC:003506

Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer: a clinical practice guideline
Program in Evidence-based Care - State/Local Government Agency [Non-U.S.]. 2001 Jan 17 (revised 2006 Mar 27). 51 pages. NGC:004953


Upcoming Events
Cancer Epigenetics
28 -  31 May 2008
Boston Park Plaza Hotel, Boston, USA
2008 ASCO Annual Meeting
30 May -  03 Jun 2008
McCormick Place, Chicago, USA
ASCO Annual Meeting
30 May -  03 Jun 2008
McCormick Place, Chicago, USA


Further Reading
Other Articles from Touch
Current Strategies in the Treatment of Advanced Non-small Cell Lung Cancer
Four-dimensional Cone Beam Computed Tomography-guided Radiotherapy for Lung Cancer Patients

Events
Update in Surgical Oncology 2007
Oct 26, 2007
The 6th Annual Providence Thoracic Oncology Symposium Specialists' Symposium on Advanced Management of Lung Cancer
Nov 17, 2007
Ninth International Lung Cancer Congress
Jun 18-21, 2008

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